Andrew Hamilton Selected Research

GGTI 298

4/2005	Inhibition of geranylgeranyltransferase I decreases generation of vascular reactive oxygen species and increases vascular nitric oxide production.
1/2004	Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis.

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Andrew Hamilton Research Topics

Disease

3	Thrombosis (Thrombus) 01/2022 - 06/2002
3	Neoplasms (Cancer) 09/2015 - 01/2004
3	Breast Neoplasms (Breast Cancer) 01/2015 - 07/2007
1	Acidosis 05/2020
1	Reinfection 03/2019
1	Endocarditis 03/2019
1	Stroke (Strokes) 01/2018
1	Renal Insufficiency (Renal Failure) 01/2018
1	Respiratory Insufficiency (Respiratory Failure) 01/2018
1	Myocardial Infarction 01/2018
1	Low Cardiac Output 01/2018
1	Prediabetic State (Prediabetes) 01/2016
1	Type 2 Diabetes Mellitus (MODY) 01/2016
1	Herpes Genitalis (Genital Herpes) 03/2015
1	Hypertrophy 03/2015
1	Pain (Aches) 03/2015
1	Inflammation (Inflammations) 03/2015
1	Carcinoma (Carcinomatosis) 01/2015
1	Multiple Myeloma 01/2015
1	Insulinoma 01/2015
1	Hepatocellular Carcinoma (Hepatoma) 01/2015
1	Nasopharyngeal Carcinoma 01/2015
1	Obstructive Sleep Apnea 03/2014
1	Atrial Fibrillation 03/2014
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2014
1	Fibrosis (Cirrhosis) 01/2014
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2014
1	Hypertensive Crisis 03/2013
1	Coronary Vasospasm (Coronary Artery Vasospasm) 03/2013
1	Chest Pain (Chest Pains) 03/2013
1	Chondrosarcoma 10/2012
1	Fistula 01/2012
1	Body Weight (Weight, Body) 03/2010
1	Acquired Immunodeficiency Syndrome (AIDS) 10/2007
1	Dyslipidemias (Dyslipidemia) 01/2007
1	Mitral Valve Stenosis (Mitral Stenosis) 12/2006
1	Malaria 06/2005
1	Hyperplasia 04/2005
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2005
1	Vascular System Injuries 04/2005
1	Chronic Disease (Chronic Diseases) 12/2004
1	Ovarian Epithelial Carcinoma 01/2004
1	Ovarian Neoplasms (Ovarian Cancer) 01/2004
1	Chagas Disease (American Trypanosomiasis) 12/2003
1	Salmonella Infections (Salmonellosis) 10/2003

Drug/Important Bio-Agent (IBA)

3	Pharmaceutical PreparationsIBA 03/2019 - 12/2003
2	geranylgeranyltransferase type-I (protein geranylgeranyltransferase)IBA 04/2009 - 04/2005
2	GGTI 298IBA 04/2005 - 01/2004
1	SugarsIBA 05/2020
1	Starch (Cornstarch)IBA 05/2020
1	Troponin IIBA 01/2018
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 01/2016
1	Hemoglobins (Hemoglobin)IBA 01/2016
1	MicroRNAs (MicroRNA)IBA 09/2015
1	Epstein-Barr virus encoded RNA 2IBA 09/2015
1	Epstein-Barr virus encoded RNA 1IBA 09/2015
1	Amyloid (Amyloid Fibrils)IBA 03/2015
1	Antiviral Agents (Antivirals)IBA 03/2015
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2015
1	serglycinIBA 01/2015
1	GadoliniumIBA 01/2014
1	Illicit Drugs (Recreational Drugs)IBA 03/2013
1	Adrenergic Antagonists (Antiadrenergic Agents)IBA 03/2013
1	TroponinIBA 03/2013
1	Cocaine (Cocaine HCl)IBA 03/2013
1	DisaccharidesIBA 10/2012
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 10/2012
1	Cyclin-Dependent Kinase Inhibitor p27IBA 04/2009
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 04/2009
1	EstersIBA 04/2009
1	Small Interfering RNA (siRNA)IBA 04/2009
1	PeptidomimeticsIBA 04/2009
1	LipidsIBA 01/2007
1	p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA 06/2005
1	EnzymesIBA 06/2005
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2005
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2005
1	Phosphotransferases (Kinase)IBA 12/2004
1	SurvivinIBA 01/2004
1	GGTI 2166IBA 01/2004
1	Cisplatin (Platino)FDA LinkGeneric 01/2004
1	Proteins (Proteins, Gene)FDA Link 10/2003
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2003
1	Fibrinogen (Factor I)FDA Link 06/2002

Therapy/Procedure

2	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 03/2014 - 09/2010
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 09/2010 - 03/2010
2	Therapeutics 04/2009 - 06/2005
2	Surgical Instruments (Clip) 10/2007 - 12/2006
1	Conservative Treatment 01/2022
1	Compression Stockings 01/2022
1	Catheters 01/2012
1	Fat-Restricted Diet (Diet, Fat Restricted) 07/2007
1	Intravenous Injections 06/2002
1	Injections 06/2002